Mechanical ventilation helps people breathe when they cannot breathe on their own. During mechanical ventilation, medications are delivered to the lungs of the person using the ventilator using aerosol therapy.Nebulizers are devices that convert a liquid mass into a fine aerosol suitable for inhalation. By utilizing the efficiency of pulmonary drug absorption, they offer a safe and powerful method for local and systemic drug delivery in the treatment of critical illnesses. Compared to conventional jet (JN) and ultrasonic nebulizers (USN), the advent of vibrating mesh nebulizers (VMN) has significantly increased the therapeutic potential of modern devices.